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A new team to explore the brain in Evry

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Genopole®, Télécom SudParis and the University of Évry welcome a new scientific team to explore the complexity of the brain.
 
L’team has settled in Évry thanks to the Genopole®'s research support systemThe Group is also supporting the University of Evry and the innovation facilities of the ETOILE center, recently opened on the campus of the Institut Mines Télécom.
 
Researcher Marco Antonio Mendoza joined the Metabolic genomics of the Genoscope laboratory (CEA / CNRS / University of Évry). It installs part of its activities in the ETOILE clean room, a rare resource present on the campus of Télécom SudParis and Institut Mines-Télécom Business School. The rigorously controlled atmosphere of the room will provide the conditions necessary for his project to explore the cellular differentiation pathways of the human brain.
 
Understanding cell differentiation
The BrainFate project of Marco Mendoza's team aims to unravel the molecular program of neurogenesis using multicellular structures produced in the laboratory. They will be analysed by a DNA chip system to produce a fine 3-dimensional map of the genes expressed in them. The aim is to understand and reconstruct the regulatory circuits that lead to cell differentiation in the nervous system. The ultimate ambition is to advance the understanding of neurodegenerative diseases.
 
An attractive search facility
After ten years of research at the Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Strasbourg, the researcher had plans to create his own team. Genopole®'s Thematic Incentive Action (ATIGE) gave him the opportunity to do so. The ATIGE scheme is specifically designed to foster the arrival of new scientific leaders on the Genopole® biocluster.
Thanks to ATIGE funding, Marco Mendoza was able to hire a post-doctoral student in neurobiology and a master's degree in bioinformatics. He was able to equip his laboratory with the robot for manufacturing DNA chips on slides (photo opposite), a key element in the success of the project.
 
This is a fine example of a successful partnership between Genopole®, Télécom SudParis, the University of Evry and local research players, based on a unifying healthcare research project.
 
Marco Mendoza says: "My arrival in the Genopole® biocluster is motivated on the one hand by the support of ATIGE for the installation of my team, but also by the ecosystem conducive to its success, in particular the variety of expertise found: the Genoscope, I-Stem's expertise in the field of stem cells, the infrastructure of the Telecom SudParis campus, etc. ».
 
For Marcel Salanoubat, Director of the UMR Metabolic Genomics, "Welcoming this new team to the unit has made it possible to strengthen activities in synthetic and systems biology. It complements Genoscope's genomics skills by providing a new technology for the spatial analysis of gene transcription during neuronal development. This technology will undoubtedly be of interest to other laboratories on site and beyond. »
 
For Jean-Marc Grognet, CEO of Genopole®, "Genopole® welcomes the arrival of Marco Mendoza's team, which is a testament to the scientific dynamism of the Evry - Corbeil area. It's also a fine demonstration of the benefits of pooling our resources as research players in order to generate promising projects and new skills.
 
Christophe Digne, director of Télécom SudParis, believes that : "The infinitesimally small cells are also at the heart of the activities of our teacher-researchers. This is a unique opportunity for digital and healthcare researchers from the University of Evry, Genopole® and Télécom SudParis to work together. »
 
As for Patrick Curmi, President of the University of Evry, he is delighted: "The arrival of Marco Mendoza, witness of the close collaboration between the actors of the Campus Évry. Our colleague's work, by providing a unique platform to explore in vitro the elementary construction processes of the brain, will increase cooperation between the site's research units and our international attractiveness".
 

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